BimS, EL, L (AA 20-40) Antikörper

Produktnummer ABIN2745516

Der Ratte Monoklonal Anti- Antikörper wurde für FACS, IP, IHC, WB, ICC und ELISA validiert. Er ist geeignet, in Proben von Maus, Hund, Human, Affe und Ratte zu detektieren.

Kurzübersicht für BimS, EL, L (AA 20-40) Antikörper (ABIN2745516)

Target: BimS, EL, L

Reaktivität: Maus, Hund, Human, Affe, Ratte

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB), Immunocytochemistry (ICC), ELISA

Klon: 3C5

Produktdetails

Bindungsspezifität: AA 20-40

Spezifität: Recognizes an epitope within aa 20-40 of human, mouse, rat, monkey and dog BimL (~19 kDa), BimEL (~23 kDa), and BimS (~16 kDa). Also recognizes the six novel isoforms of human Bim, generated by alternative splicing and lacking the C-terminal hydrophobic region.

Kreuzreaktivität: Hund, Human, Affe, Maus, Ratte (Rattus)

Reinheit: >95 % (SDS-PAGE)

Endotoxin-Niveau: <0.1EU/μg purified protein (LAL test, Lonza).

Immunogen: Synthetic peptide corresponding to aa 20-40 of mouse BimL.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS containing 0.02 % sodium azide and 25 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Antigendetails

Target: BimS, EL, L

Andere Bezeichnung: BimS/EL/L

Hintergrund: Bim belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the Bcl-2 protein family (BCL2, BCL2L1/BCL-X(L) and MCL1) and to act as an apoptotic activator, inducing apoptosis and anoikis. Several variants have been identified. The isoforms vary in cytotoxicity with isoform BimS being the most potent and isoform BimEL being the least potent.